WebThe beneficial effect of HSYA was generally superior to that of Edaravone. Molecular modeling suggested that HSYA may bind strongly to HIF-1 α, BNIP3, and Notch1 but weakly to LC3. In conclusion, HSYA inhibits post-IS autophagy induction in the brain, possibly by suppressing HIF-1 α, BNIP3 and Notch1. Web1 de set. de 2001 · To additionally check the role of Hif-1α in BNIP3 induction, CHO KA13 and C4.5 cells were subjected to normoxia or hypoxia for 16 h before being analyzed …
The Absence of HIF-1α Increases Susceptibility to Leishmania …
WebHIF-1 and HIF-2 appear to be evenly matched in their capacity to induce BNIP3-dependent autophagy. In agreement with these studies, HIF-1-dependent expression of BNIP3 was described to be essential in mitochondrial autophagy (also called mitophagy), as described in MEFs (Zhang et al., 2008) and later in mole rat heart tissue (Band et al., 2009). Web15 de jun. de 2024 · Unlike HIF-1α and REDD1 (expressed transiently), Bnip3 was time-dependently induced by iron chelation, and high levels of Bnip3 were detectable after 24-h treatment with CPX or Dp44mT (Fig. S4A, B). brinton lakes
BNIP3 Gene - GeneCards BNIP3 Protein BNIP3 Antibody
Webbnip3的表达受到转录因子hif-1a的调控,在低氧诱导细胞自噬凋亡过程中起重要的作用。 然而,唾液腺腺样囊性癌中BNIP3的表达、其调节的低氧诱导自噬通路及临床病理学行为国内外尚未有文献报道。 Web13 de jul. de 2024 · Hypoxia-inducible factor-1 (HIF-1) dependent expressions of DRP1 and phosphorylated DRP1 and mitophagy-related protein BNIP3 were significantly upregulated in hypoxia-surviving HCC cells (Fig. 1e). Web13 de jun. de 2008 · Cell Death & Differentiation - Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Skip to main content. … brinton vision mo